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Medical Index
First Posted Apr 22, 2008
Jul 28, 2010

Small Strongyles Developing Resistance to Ivermectin

The following article appeared in the Horse Health Newsletter. Nothing has been omitted from that article.

Study: Small Strongyles Developing Resistance to Ivermectin
by: Stacey Oke, DVM, MSc
April 14 2008, Article #11668
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Researchers in Central Kentucky have suggested that small strongyles might be developing resistance to ivermectin (a commonly administered broad spectrum anti-parasitic drug). The scientists found that the number of parasite eggs in study horses' manure returned twice as quickly after treatment with ivermectin compared to when the drug was first marketed in the early 1980s. Previous studies have shown that small strongyles--a common intestinal parasite of horses--have developed a resistance to numerous drugs since the 1950s including phenothiazine, thiabendazole, pyrantel pamoate, and piperazine. Recent studies have also suggested that resistance to ivermectin and moxidectin was also developing.

"The purpose of this study was to determine the current status of the efficacy of ivermectin against small strongyles in horses," explained Eugene Lyons, PhD, from the Gluck Equine Research Center in Kentucky.

"This is a real and serious dilemma for the equine industry." --Dr. Eugene Lyons. This study evaluated the activity of ivermectin by counting the number of strongyle eggs per gram of feces before and after treatment with ivermectin. All horses included in this study resided on a single farm located in Central Kentucky. "Our results showed that the fecal egg counts of small strongyles returned faster than expected--approximately twice as quickly," said Lyons. "This data suggests that a resistance to ivermectin is developing."

This suspected ivermectin resistance has also been reported in other geographic areas, including countries outside of the United States. More detailed studies evaluating the degree of removal of small strongyles after treating horses with ivermectin and the related drug moxidectin are required to verify the data collected in this field study.

According to Lyons, no alternate drugs are available and no new drugs effective against small strongyles are forthcoming on the market.

"This is a real and serious dilemma for the equine industry," stated Lyons.

The study, "Field studies indicating reduced activity of ivermectin on small strongyles in horses on a farm in Central Kentucky" is schedule for publication in an upcoming edition of the journal Parasitologica Research.

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