Abstracts and Studies
|First Posted: Apr 8, 2011 |
Jan 16, 2012
Toxicology of deoxynivalenol (vomitoxin).
Rotter BA, Prelusky DB, Pestka JJ.
Centre for Food and Animal Research, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Abstract"Trichothecene mycotoxins are a group of structurally similar fungal metabolites that are capable of producing a wide range of toxic effects. Deoxynivalenol (DON, vomitoxin), a trichothecene, is prevalent worldwide in crops used for food and feed production, including in Canada and the United States. Although DON is one of the least acutely toxic trichothecenes, it should be treated as an important food safety issue because it is a very common contaminant of grain. This review focuses on the ability of DON to induce toxicologic and immunotoxic effects in a variety of cell systems and animal species. ..."